P. Milpied

The immune profile of circulating autoreactive CD4 T cells is imprinted through tissue activation during autoimmune liver diseases

This study identifies the transcriptional profile of circulating autoreactive CD4 T cells in autoimmune liver diseases and shows their functional relationship to liver-specific pathogenic clones.

Functional plasticity and recurrent cell states of malignant B cells in follicular lymphoma

This study identifies recurrent malignant B cell states in follicular lymphoma using single-cell RNA-seq and shows their functional plasticity and niche-specific localization.

A novel mouse model based on intersectional genetics enables unambiguous in vivo discrimination between plasmacytoid and other dendritic cells and their comparative characterization

This paper develops a pDC-reporter mouse model to unambiguously identify and compare pDC, pDC-like cells, and tDC in vivo, revealing distinct activation patterns during viral infection.

Viral infection engenders bona fide and bystander lung memory B cell subsets through permissive selection

The paper identifies two distinct lung memory B cell subsets post-viral infection, showing they arise from different progenitors and are classified as virus-specific or bystander based on antigen specificity.

An NF-κB/IRF1 axis programs cDC1s to drive anti-tumor immunity

This study identifies the NF-κB/IRF1 axis as critical for cDC1 maturation and anti-tumor immunity, showing its role in CD8+ T cell activation and tumor control.

Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

The paper characterizes autoreactive CD4 T cells in autoimmune hepatitis patients, identifying a specific phenotype linked to disease activity and IgG response.

FB5P-seq: FACS-based 5-prime end single-cell RNAseq for integrative analysis of transcriptome and antigen receptor repertoire in B and T cells