M. Valente

Immunofilaments Provide a Nanoscale Platform for In Vivo T Cell Expansion and Cancer Immunotherapy

This paper introduces immunofilaments that expand T cells in vivo, showing efficacy against melanoma when combined with immune checkpoint blockade.

Native doublet microtubules from Tetrahymena thermophila reveal the importance of outer junction proteins

The paper uses cryo-EM to analyze native doublet microtubules in Tetrahymena thermophila, identifying MIPs and showing their role in cilia function through CFAP77 knockout.

A novel mouse model based on intersectional genetics enables unambiguous in vivo discrimination between plasmacytoid and other dendritic cells and their comparative characterization

This paper develops a pDC-reporter mouse model to unambiguously identify and compare pDC, pDC-like cells, and tDC in vivo, revealing distinct activation patterns during viral infection.

Hypoxia promotes a perinatal-like progenitor state in the adult murine epicardium

This study shows that hypoxia reactivates progenitor-like properties in adult murine epicardial cells, promoting endothelial fate and multilineage differentiation potential.

Fibroadipogenic Progenitors contribute to microvascular repair during skeletal muscle regeneration

This study shows that fibroadipogenic progenitors (FAPs) differentiate into endothelial cells during skeletal muscle regeneration in response to hypoxia and glucose deprivation.

Remodeling and activation mechanisms of outer arm dyneins revealed by cryo-electron microscopy

This study uses cryo-electron microscopy to reveal the structure of outer dynein arms attached to microtubules and proposes a model for their remodeling and activation through molecular dynamics simulations.

Chronic pain alters microvascular architectural organization of somatosensory cortex

This study identifies microvascular neogenesis in somatosensory cortex of chronic pain models, suggesting altered vascular architecture with potential implications for CP diagnosis and treatment.

Functional diversification of hybridoma produced antibodies by CRISPR/HDR genomic engineering

This study presents a CRISPR/HDR platform to engineer hybridoma antibodies for diverse isotypes, formats, and species, enabling functional antibody diversification.