Author

T. Lawrence

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

D. R. Withers· 2 shared D. Sosnowska· 2 shared I. Dean· 2 shared J. Caron· 2 shared J. E. Anstee· 2 shared J. N. Arnold· 2 shared J. W. Opzoomer· 2 shared S. Kordasti· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

D. R. Withers

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Jagged-1+ Tregs Mediate Lymphatic Remodeling in Tumour-Draining Lymph Nodes

J. Z. Xu, P. P. Lui, P.-H. Tsai, H. Aziz, B. Xie, I. Cho, M. Terranova-Barberio, C. Z. Li, K. Stoker, H. Yu, A. E. Denton, T. Lawrence, S. N. Karagiannis, N. Ali

This study shows that Jag1-expressing regulatory T cells (Tregs) in tumor-draining lymph nodes (tdLNs) are essential for lymphatic remodeling and niche formation during melanoma progression.

bioRxiv · Jun 10, 2024 · PreprintImmunology

A Shape Sensing Mechanism driven by Arp2/3 and cPLA2 licenses Dendritic Cells for Migration to Lymph Nodes in Homeostasis

Z. Alraies, C. A. Rivera, M.-G. Delgado, D. Sanseau, M. Maurin, R. Amadio, G. Maria Piperno, G. Dunsmore, A. Yatim, L. Lacerda Mariano, P. Saez, M. Gratia, O. Lamiable, A. Moreau, A. Williart, , A.-M. Lennon-Dumenil

The paper identifies a shape sensing mechanism in dendritic cells that links cell motility to CCR7 expression, enabling migration to lymph nodes through ARP2/3-cPLA2 signaling.

bioRxiv · Aug 9, 2022Cell Biology

Targeting TRIP13 in Wilms Tumor with Nuclear Export Inhibitors

K. Mittal, B. P. Lee, G. W. Cooper, J. Shim, H. C. Jonus, W. J. Kim, M. Doshi, D. Almanza, B. D. Kynnap, A. L. Christie, X. Yang, G. S. Cowley, B. A. Leeper, C. L. Morton, B. Dwivedi, , A. L. Hong

This study identifies XPO1 inhibition with selinexor as a potential therapy for favorable histology Wilms tumors, showing synergy with doxorubicin in preclinical models.

bioRxiv · Feb 23, 2022Cancer Biology

Perivascular macrophages collaborate to facilitate chemotherapy resistance in cancer

J. E. Anstee, J. W. Opzoomer, I. Dean, H. P. Muller, M. Bahri, K. Liakath-Ali, Z. Liu, D. Choy, J. Caron, D. Sosnowska, R. Beatson, T. Muliaditan, Z. An, C. E. Gillett, G. Lan, , J. N. Arnold

This study identifies Lyve-1+ perivascular macrophages that form nests and contribute to chemotherapy resistance by excluding CD8+ T-cells and relying on IL-6 and CCR5/CCL3/4 signaling.

bioRxiv · Feb 3, 2022Cancer Biology

An NF-κB/IRF1 axis programs cDC1s to drive anti-tumor immunity

G. Ghislat, A. S. Cheema, E. Baudoin, C. Verthuy, P. Ballester, K. Crozat, N. Attaf, C. Dong, P. Milpied, B. Malissen, N. Auphan-Anezin, T.-P. V. Manh, M. Dalod, T. Lawrence

This study identifies the NF-κB/IRF1 axis as critical for cDC1 maturation and anti-tumor immunity, showing its role in CD8+ T cell activation and tumor control.

bioRxiv · Dec 28, 2020Immunology

Macrophages orchestrate the expansion of a pro-angiogenic perivascular niche during cancer progression

J. W. Opzoomer, J. E. Anstee, I. Dean, E. J. Hill, I. Bouybayoune, J. Caron, T. Muliaditan, P. Gordon, D. Sosnowska, R. Nuamah, S. E. Pinder, T. Ng, F. Dazzi, S. Kordasti, D. R. Withers, , J. N. Arnold

This study identifies Lyve-1+ tumor-associated macrophages that support tumor growth by maintaining a pro-angiogenic perivascular niche through platelet-derived growth factor-CC-dependent expansion of mesenchymal cells.

bioRxiv · Oct 30, 2020Cancer Biology

Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer

J. Guillot, C. Dominici, A. Lucchesi, T. T. H. Nguyen, J. Nigri, F. Guillaumond, M. Bigonnet, N. Dusetti, A. Etzerodt, T. Lawrence, P. Pudlo, F. Hubert, J.-Y. Scoazec, S. A. van de Pavert, R. Tomasini, , F. Mann

This study shows that sympathetic axonal sprouting alters macrophage populations and reduces pancreatic cancer progression.

bioRxiv · Apr 27, 2020Cancer Biology