Author

L. Spinelli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 9 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 6 Organism:human· 6 Research Focus:cell signaling & trafficking· 5 Organism:mouse· 4 Assay:proteomics· 4 Research Focus:development & morphogenesis· 3 Research Focus:differential expression· 3

Frequent Co-Authors

D. A. Cantrell· 5 shared A. J. Howden· 3 shared C. Dong· 3 shared J. M. Marchingo· 3 shared L. Gil· 3 shared L. V. Sinclair· 3 shared P. Milpied· 3 shared A. I. Lamond· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersImmunology

D. A. Cantrell

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells.

L. V. Sinclair, T. Youdale, L. Spinelli, M. Gakovic, A. J. Landlands, S. Pathak, A. J. Howden, I. Ganley, D. A. Cantrell

This study shows antigen and cytokines repress autophagy in CD8 T cells, shaping mitochondrial function, migration, and effector machinery through differential proteome pruning.

bioRxiv · Jun 10, 2024Immunology

PIM kinase control of CD8 T cell protein synthesis and cell trafficking

J. M. Marchingo, L. Spinelli, S. Pathak, D. A. Cantrell

This study shows PIM kinases selectively regulate IL-2-driven protein synthesis and trafficking in CD8 T cells, without major effects on transcriptional programs.

bioRxiv · Mar 25, 2024Immunology

The Immunological Proteome Resource

A. J. Brenes, J. L. Hukelmann, L. Spinelli, A. J. M. Howden, J. M. Marchingo, L. V. Sinclair, C. Rollings, O. J. James, I. R. Phair, S. P. Matthews, S. H. Ross, S. C. Arthur, M. Swamy, D. K. Finlay, A. I. I. Lamond, D. A. Cantrell

The paper introduces ImmPRes, a proteomic resource integrating mass-spectrometry data from murine hematopoietic cells to study immune activation and signaling.

bioRxiv · Aug 29, 2022Immunology

Functional plasticity and recurrent cell states of malignant B cells in follicular lymphoma

N. Attaf, C. Dong, L. Gil, I. Cervera-Marzal, T. Gharsalli, J.-M. Navarro, D.-L. Mboumba, L. Chasson, F. Lemonnier, P. Gaulard, S. Roulland, L. Spinelli, B. Nadel, P. Milpied

This study identifies recurrent malignant B cell states in follicular lymphoma using single-cell RNA-seq and shows their functional plasticity and niche-specific localization.

bioRxiv · Apr 6, 2022 · PreprintCancer Biology

Type III interferons induce pyroptosis in gut epithelial cells and delay tissue restitution upon acute intestinal injury.

B. Sposito, J. Mambu, K. Bugda Gwilt, L. Spinelli, N. Andreeva, F. Galland, P. Naquet, V. Mitsialis, J. R. Thiagarajah, S. Snapper, A. Broggi, I. Zanoni

This study shows type III interferons delay intestinal tissue repair by inducing pyroptosis in epithelial cells after injury.

bioRxiv · Mar 4, 2022 · PreprintImmunology

Viral infection engenders bona fide and bystander lung memory B cell subsets through permissive selection

C. Gregoire, L. Spinelli, S. Villazala-Merino, L. Gil, M. Moussa, C. Dong, A. Zarubica, M. Fallet, J.-M. Navarro, B. Malissen, P. Milpied, M. Gaya

The paper identifies two distinct lung memory B cell subsets post-viral infection, showing they arise from different progenitors and are classified as virus-specific or bystander based on antigen specificity.

bioRxiv · Dec 14, 2021 · PreprintImmunology

Tissue environment, not ontogeny, defines intestinal intraepithelial T lymphocytes

A. J. Brenes, M. Vandereyken, O. J. James, J. Hukelmann, L. Spinelli, A. I. Lamond, M. Swamy

The paper uses proteomic analysis to show that the gut environment, not developmental origin, shapes the functional properties of intestinal intraepithelial T lymphocytes.

bioRxiv · Mar 15, 2021Immunology

Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation

M. P. Damasio, J. M. Marchingo, L. Spinelli, D. A. Cantrell, A. J. Howden

This study uses mass spectrometry to identify ERK-regulated proteins in CD8+ T cells and reveals their role in transcriptional reprogramming and cytokine expression during activation.

bioRxiv · Aug 18, 2020Immunology

FB5P-seq: FACS-based 5-prime end single-cell RNAseq for integrative analysis of transcriptome and antigen receptor repertoire in B and T cells

N. Attaf-Bouabdallah, I. Cervera-Marzal, C. Dong, L. Gil, A. Renand, L. Spinelli, P. Milpied

bioRxiv · Oct 7, 2019Immunology

Antigen receptor control of methionine metabolism in T cells

L. V. Sinclair, A. J. Howden, A. J. Brenes-Murillo, L. Spinelli, J. L. Hukelmann, A. N. Macintyre, X. Liu, S. Thomson, P. M. Taylor, J. C. Rathmell, J. W. Locasale, A. I. Lamond, D. A. Cantrell

This study shows antigen receptor engagement controls methionine cycle flux and methyl donor availability for RNA and histone methylation in T cells.

bioRxiv · Dec 18, 2018Immunology