M. Dalod

Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections

This study shows that plasmacytoid dendritic cells (pDCs) and their interferons are dispensable or harmful in systemic and respiratory viral infections in mice.

DCs targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors

The paper shows that DC-based therapy enhances CD8 T cell responses to neoantigens in lung tumors, particularly in high TMB tumors.

A gene silencing pipeline to interrogate human cDC1 and pDC development and functions

This paper develops a gene silencing pipeline to study human cDC1 and pDC development and functions, identifying key regulators and HIV-1 restriction factors.

M-CSF induces a coordinated myeloid and NK cell differentiation program protecting against CMV after hematopoietic cell transplantation

This study shows M-CSF promotes antiviral immunity against CMV after HCT by enhancing myeloid and NK cell differentiation and IL-15/IFN signaling.

A novel mouse model based on intersectional genetics enables unambiguous in vivo discrimination between plasmacytoid and other dendritic cells and their comparative characterization

This paper develops a pDC-reporter mouse model to unambiguously identify and compare pDC, pDC-like cells, and tDC in vivo, revealing distinct activation patterns during viral infection.

An NF-κB/IRF1 axis programs cDC1s to drive anti-tumor immunity

This study identifies the NF-κB/IRF1 axis as critical for cDC1 maturation and anti-tumor immunity, showing its role in CD8+ T cell activation and tumor control.

cDC1 and interferons promote spontaneous CD4+ and CD8+ T cell protective responses to breast cancer

This study shows that cDC1 and interferons are critical for CD4+ and CD8+ T cell responses against breast cancer, promoting infiltration and effector functions, and improving patient prognosis.

Open Source ImmGen: network perspective on metabolic diversity among mononuclear phagocytes

The paper analyzes metabolic diversity in mononuclear phagocytes across tissues using integrated datasets and a network-based approach, identifying key metabolic subnetworks and their functional roles.

NK cells orchestrate splenic cDC1 migration to potentiate antiviral protective CD8+ T cell responses

The paper shows NK cells guide cDC1 migration in the spleen to enhance antiviral CD8+ T cell responses during infection.