B. Ueberheide

Identification of SLC25A46 interaction interfaces with mitochondrial membrane fusogens Opa1 and Mfn2

This study identifies interaction interfaces between SLC25A46 and mitochondrial fusion proteins Opa1 and Mfn2 using crosslinking mass-spectrometry and AlphaFold 2 modeling.

Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under Oxidative Stress

This study reveals how two F-box proteins, FBXO22 and FBXL17, recognize distinct structural features of the BACH1 BTB dimer under oxidative stress, leading to its ubiquitination and degradation.

Geranylgeranylated-SCFFBXO10 Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function

This study identifies how geranylgeranylation of FBXO10 enables its targeting to the outer mitochondrial membrane, where it regulates PGAM5 ubiquitination and mitochondrial function.

D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability

This study shows D-type cyclins inhibit mismatch repair (MMR) in G1 phase by shielding p21, while their degradation in S phase enables proper MMR function, maintaining genome stability.

Identification of a Hypoxia-induced Inflammatory Cell Death Pathway

The paper identifies a hypoxia-induced inflammatory cell death pathway involving PTP1B, RNF213, and CYLD/SPATA2, showing their role in tumor cell death and potential therapeutic targeting.

Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation

The paper shows that glucose uptake via GLUT1 co-endocytoses with PDGF receptor upon PDGF stimulation, delivering glucose to mitochondria for glycolysis.

Cell wall proteomics in live Mycobacterium tuberculosis uncovers exposure of ESX substrates to the periplasm

This study identifies cell wall proteins in Mycobacterium tuberculosis using APEX2 tagging, revealing ESX substrate exposure to the periplasm.

Structure of an endogenous mycobacterial MCE lipid transporter

The paper reports the cryo-EM structure of the Mce1 fatty acid import machine from Mycobacterium smegmatis, revealing its assembly and a previously unknown subunit, LucB.

Mitochondrial DNA Breaks Activate an Integrated Stress Response to Reestablish Homeostasis

This study investigates how mitochondrial DNA breaks trigger an integrated stress response to restore mitochondrial homeostasis.

Optical Control of Membrane Fluidity Modulates Protein Secretion

This paper introduces an optical method to control membrane fluidity using a synthetic fatty acid with an azobenzene photoswitch, demonstrating its impact on protein secretion from the ER.

Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

The paper identifies somatostatin venom analogs from fish-hunting cone snails, showing their potential as therapeutic leads for pain, cancer, and endocrine disorders.

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

This study identifies drug-tolerant persisters (DTPs) in HER2+ breast cancer and reveals their origins and vulnerabilities to TKI resistance.

Mycobacterium tuberculosis Rv0991c is a redox-regulated molecular chaperone

This paper identifies Rv0991c in M. tuberculosis as a redox-regulated molecular chaperone essential for virulence, functioning similarly to Hsp33 in E. coli.

Identification of PIM1 substrates reveals a role for NDRG1 in prostate cancer cellular migration and invasion

This study identifies PIM1 substrates in prostate cancer cells, revealing that PIM1 phosphorylates NDRG1, reducing its stability and function in suppressing cell migration and invasion.

A DNA-guided Argonaute Protein Functions in DNA Replication in Thermus thermophilus

The DNA-guided Argonaute protein TtAgo in Thermus thermophilus aids in separating daughter chromosomes after DNA replication.

Melanoma-secreted Amyloid Beta Supresses Neuroinflammation and Promotes Brain Metastasis

This study identifies amyloid beta as a factor secreted by melanoma cells that suppresses neuroinflammation and promotes brain metastasis.

The Mycobacterium tuberculosis Pup-proteasome system regulates nitrate metabolism through an essential protein quality control system

This study shows that the M. tuberculosis proteasome system regulates nitrate metabolism by controlling chaperonin gene expression through proteasome-mediated degradation of HrcA.

USP7 cooperates with NOTCH1 to drive the oncogenic transcriptionalprogram in T cell leukemia

This study identifies USP7 as a key driver of T-cell leukemia by stabilizing NOTCH1 and JMJD3, showing USP7 inhibition blocks leukemia growth and suggests it as a therapeutic target.

LINE-1 and the cell cycle: protein localization and functional dynamics

This study identifies L1 protein nuclear entry mechanisms and shows a cell cycle bias for L1 retrotransposition peaking in S phase.

The integrated stress response pathway activates 4E-BP to bias mRNA translation and boost antimicrobial peptide synthesis in response to bacterial infection

This study shows that 4E-BP, induced by GCN2/ATF4 during bacterial infection, promotes cap-independent translation of antimicrobial peptides in Drosophila.