Author

P. O'Toole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:electrophysiology· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

R. Suman· 2 shared A. D. James· 1 shared A. Franke· 1 shared A. Lindqvist· 1 shared A. Peters· 1 shared A. W. Middleton· 1 shared B. Linkohr· 1 shared C. I. Le Roy· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

R. Suman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

p53-dependent polyploidisation after DNA damage in G2 phase

A. W. Middleton, R. Suman, P. O'Toole, K. Akopyan, A. Lindqvist

This study shows that G2 phase cell cycle exit in p53-positive cells can lead to polyploidisation through repeated DNA re-replication rather than senescence.

bioRxiv · Jun 9, 2020 · PreprintCell Biology

Arrhythmic gut microbiome signatures for risk profiling of Type-2 Diabetes

S. Reitmeier, S. Kiessling, T. Clavel, M. List, E. L. Almeida, T. G. Ghosh, K. Neuhaus, M. Troll, H. Grallert, W. Rathmann, B. Linkohr, A. Franke, C. I. Le Roy, J. Bell, T. Spector, , D. Haller

The paper identifies arrhythmic gut microbiome signatures associated with Type-2 Diabetes risk and validates them in a separate cohort.

bioRxiv · Dec 27, 2019Microbiology

Voltage-dependent activation of Rac1 by Nav1.5 channels promotes cell migration

M. Yang, A. D. James, R. Suman, R. Kasprowicz, M. Nelson, P. O'Toole, W. J. Brackenbury

The paper shows Nav1.5 channels depolarize the membrane potential, increasing Rac1 activation and promoting cell migration.

bioRxiv · Aug 9, 2019Cell Biology