Author

W. J. Brackenbury

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 4 Cancer Biology· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 4 Assay:electrophysiology· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:imaging· 2

Frequent Co-Authors

A. D. James· 4 shared S. Chawla· 3 shared T. K. Leslie· 3 shared L. Wiggins· 2 shared M. Nelson· 2 shared N. Sajjaboontawee· 2 shared A. Holding· 1 shared A. J. Kennerley· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

A. D. James

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Exploring the impact of variability in cell segmentation and tracking approaches

L. Wiggins, P. J. O'Toole, W. J. Brackenbury, J. Wilson

The paper quantifies variability in manual and automated cell segmentation and tracking methods, showing their impact on phenotypic metrics and reproducibility.

bioRxiv · Nov 24, 2023Cell Biology

A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis

T. K. Leslie, A. Tripp, A. D. James, S. P. Fraser, M. Nelson, N. Sajjaboontawee, M. S. Toss, W. Fadhil, S. C. Salvage, M. Arias Garcia, M. Beykou, E. Rakha, V. Speirs, C. Bakal, G. Poulogiannis, , W. J. Brackenbury

This study identifies a Nav1.5-dependent feedback loop that links extracellular acidification to Na+ influx, promoting breast cancer metastasis.

bioRxiv · Jun 16, 2023Cancer Biology

Hypoxic volatile metabolic markers in the MDA-MB-231 breast cancer cell line

T. Issitt, M. Reilly, S. T. Sweeney, W. J. Brackenbury, K. Redeker

This study identifies four volatile organic compounds altered in MDA-MB-231 breast cancer cells under hypoxia using gas chromatography mass spectrometry.

bioRxiv · Mar 2, 2023 · PreprintCell Biology

Sodium regulates PLC and IP3R-mediated calcium signalling in invasive breast cancer cells

A. D. James, K. P. Unthank, I. Jones, N. Sajjaboontawee, R. E. Sizer, S. Chawla, G. J. O. Evans, W. J. Brackenbury

This study shows that sodium depletion in breast cancer cells increases intracellular calcium via PLC and IP3R pathways, highlighting a link between Na+ and Ca2+ signaling in metastatic cells.

bioRxiv · Aug 10, 2022 · PreprintCancer Biology

Subcellular dynamics and functional activity of the cleaved Na+ channel β1 subunit intracellular domain

A. S. Haworth, S. L. Hodges, A. L. Capatina, L. L. Isom, C. G. Baumann, W. J. Brackenbury

This study investigates the functional role of the cleaved β1 subunit intracellular domain in breast cancer cells, showing it increases Na+ current and modulates TTX-sensitive subunit expression.

bioRxiv · Dec 29, 2021Cell Biology

Sodium accumulation in breast cancer predicts malignancy and treatment response

A. D. James, T. K. Leslie, J. D. Kaggie, L. Wiggins, L. Patten, J. M. O'Duinn, S. Langer, M.-C. Labarthe, F. Riemer, G. Baxter, M. A. McLean, F. J. Gilbert, A. J. Kennerley, W. J. Brackenbury

This study uses 23Na MRI to show elevated sodium levels in breast tumors, which correlate with malignancy and treatment response, offering a non-invasive biomarker.

bioRxiv · Apr 14, 2021Cancer Biology

Inhibitory effect of eslicarbazepine acetate and S-licarbazepine on Nav1.5 channels

T. K. Leslie, L. Bruckner, S. Chawla, W. J. Brackenbury

This study shows that eslicarbazepine acetate and S-licarbazepine inhibit Nav1.5 channels, potentially explaining prolonged PR intervals and suggesting possible anti-invasion effects in cancer.

bioRxiv · Apr 24, 2020Pharmacology & Toxicology

Voltage-dependent activation of Rac1 by Nav1.5 channels promotes cell migration

M. Yang, A. D. James, R. Suman, R. Kasprowicz, M. Nelson, P. O'Toole, W. J. Brackenbury

The paper shows Nav1.5 channels depolarize the membrane potential, increasing Rac1 activation and promoting cell migration.

bioRxiv · Aug 9, 2019Cell Biology