D. Haller

Microbiota metabolized Bile Acids accelerate Gastroesophageal Adenocarcinoma via FXR inhibition

This study shows that high-fat diets promote GEAC by altering the microbiota-Bile Acid axis and inhibiting FXR, with FXR agonists like OCA slowing disease progression.

Ultra-sensitivity metaproteomics redefines the gut dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal inflammatory diseases.

The paper introduces uMetaP, an ultra-sensitive metaproteomic method that enhances detection of the gut dark metaproteome and identifies drug targets in intestinal inflammatory diseases.

Endoplasmic reticulum stress signaling actively contributes to therapy resistance in colorectal cancer

This study investigates how ER stress signaling contributes to therapy resistance in colorectal cancer by analyzing genomic alterations and testing therapeutic responses in cell lines and organoids.

ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

This study shows ATF6 activation in colonic epithelial cells alters lipid metabolism, promoting tumor-associated microbial adaptation in mice and human colorectal cancer patients.

Diurnal rhythmicity of fecal microbiota and metabolite profiles in the first year of life: a randomized controlled interventional trial with infant formula

This study shows that microbiota and metabolite rhythmicity develops early in life, influenced by diet and breastfeeding, with GOS-supplemented formula promoting bifidobacteria.

Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease

The paper shows mitochondrial dysfunction in intestinal epithelium leads to microbiota-dependent injury and identifies gene signatures that distinguish active from inactive inflammation in IBD.

Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer

The paper shows that secondary bile acids from gut bacteria worsen colorectal cancer in a Western diet model.

Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation

This study shows that altering meal timing (restricted feeding) can restore intestinal clock function and reduce inflammation in IBD models.

Gut microbial disruption in critically ill patients with COVID-19 associated pulmonary aspergillosis

This study investigates the gut and bronchial microbiota in critically ill COVID-19 patients with and without CAPA, finding reduced gut diversity and increased Staphylococcus epidermidis in CAPA patients.

Genetic and environmental circadian disruption induce metabolic impairment through changes in the gut microbiome

This study shows that circadian disruption from genetic and environmental factors causes metabolic issues by altering gut microbiome function and rhythmicity.

A translational swine model for Crohn`s disease

This paper develops a genome-edited swine model of Crohn's disease that replicates key human disease features to enable translational research.

Diet prevents the expansion of segmented filamentous bacteria and ileo-colonic inflammation in a model of Crohn's disease

This study shows that diet can prevent ileo-colonic inflammation in a Crohn's disease model by reducing segmented filamentous bacteria (SFB) abundance.

Metabolic plasticity of serine metabolism is crucial for cGAS/STING-signalling and innate immune response to viral infections in the gut

The paper identifies metabolic changes in serine metabolism linked to cGAS/STING-signalling and immune response in gut inflammation.

The intestinal circadian clock drives microbial rhythmicity to maintain gastrointestinal homeostasis

This study shows that the host's intestinal circadian clock regulates microbial rhythms, maintaining gut homeostasis through metabolite production and immune system modulation.

Gut Bacterial Dysbiosis and Instability is Associated with the Onset of Complications and Mortality in COVID-19

The paper analyzes gut and oral microbiota in COVID-19 patients to show associations between microbial dysbiosis, complications, and mortality.

Longitudinal profiles of dietary and microbial metabolites in formula- and breastfed infants

The paper examines fecal metabolites in formula- and breastfed infants to compare dietary and microbial influences on the gut metabolome over the first year of life.

Arrhythmic gut microbiome signatures for risk profiling of Type-2 Diabetes

The paper identifies arrhythmic gut microbiome signatures associated with Type-2 Diabetes risk and validates them in a separate cohort.