Author

P. Santofimia-Castano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

J. L. Iovanna· 2 shared A. Carrier· 1 shared A. Gonzalez· 1 shared C. Pin· 1 shared G. A. Lomberk· 1 shared J. Bintz· 1 shared J. l. Neira· 1 shared M. Bocchio· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

J. L. Iovanna

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintFeb 18, 2020

The stress-induced protein NUPR1 orchestrates protein translation during ER-stress by interacting with eIF2α

M. T. Borrello, P. Santofimia-Castano, M. Bocchio…·J. L. Iovanna

This paper identifies NUPR1's role in ER stress response by interacting with eIF2α to regulate protein translation recovery.

DOI 10.1101/2020.02.18.954115

mouseproteomics

𝕏 PostBluesky

Cell BiologybioRxivMar 6, 2018

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis

J. L. Iovanna, P. Santofimia-Castano, W. Lan…·P. Soubeyran

This paper shows that inactivating NUPR1 in pancreatic cancer cells causes ER stress, mitochondrial dysfunction, and necrotic cell death independent of caspases.

DOI 10.1038/s41598-018-35020-3

mousebulk RNA-seq

𝕏 PostBluesky