SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum
L. Wang, Y. Xu, S. Yun, Q. Yuan, P. Satpute-Krishnan, Y. Ye
The paper identifies SAYSD1 as a sensor of ribosome UFMylation that facilitates TAQC by interacting with the translocon and UFM1 to degrade stalled proteins, maintaining ER homeostasis.
bioRxiv · Dec 5, 2022Cell Biology