S. Yun

A Novel Subtype of Myeloproliferative Neoplasms Driven by a MYC-Alarmin Axis

This study identifies a MYC-S100A9 axis driving triple negative myelofibrosis and shows it is a therapeutic target.

Highly effective gene inactivation in tetraploid Xenopus laevis with low-temperature-active engineered Cas12a

This study evaluates engineered Cas12a variants for gene inactivation in Xenopus laevis, finding that Cas12a-Ultra achieves high efficiency at low temperatures.

Behavioral pattern separation and cognitive flexibility are enhanced in a mouse model of increased lateral entorhinal cortex-dentate gyrus circuit activity

This study shows that increasing lateral entorhinal cortex-dentate gyrus circuit activity in mice improves behavioral pattern separation and cognitive flexibility, along with increased neurogenesis.

SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum

The paper identifies SAYSD1 as a sensor of ribosome UFMylation that facilitates TAQC by interacting with the translocon and UFM1 to degrade stalled proteins, maintaining ER homeostasis.

Differential metabolic adaptations define responses of winner and loser oncogenic mutant stem cells in skin epidermis in vivo

The paper investigates metabolic adaptations in winner and loser oncogenic mutant stem cells in skin epidermis, revealing distinct metabolic strategies that drive cell competition outcomes.

Injury suppresses Ras cell competitive advantage through enhanced wild-type cell proliferation

Injury-repair selectively induces wild-type cell proliferation to suppress oncogenic growth in Ras-mosaic skin epithelium.

Effects of a 33-ion sequential beam galactic cosmic ray analog on male mouse behavior and evaluation of CDDO-EA as a radiation countermeasure

This study examines the effects of 33-ion galactic cosmic ray analog exposure on male mouse behavior and evaluates CDDO-EA as a potential countermeasure, finding no effect on exploration or anxiety but deficits in social novelty preference.

Multi-domain touchscreen-based cognitive assessment of C57BL/6J female mice shows whole body exposure to 56Fe particle space radiation in maturity improves discrimination learning yet impairs stimulus-response habit learning

This study shows that whole-body exposure to 56Fe radiation in mature female C57BL/6J mice improves hippocampal-dependent discrimination learning but impairs striatal-dependent rule-based learning.

Defective flow-migration coupling causes arteriovenous malformations in hereditary hemorrhagic telangiectasia

This study shows that defective flow-migration coupling due to ALK1 loss causes arteriovenous malformations in HHT, with integrin-YAP/TAZ signaling as a potential therapeutic target.

Analysis of the blood microbiome in a porcine model of fecal-induced peritonitis

This study analyzes the blood microbiome in a porcine model of fecal-induced peritonitis, finding stable bacterial populations and taxonomic differences between fecal and blood microbiomes.

Does chronic systemic injection of the DREADD agonists clozapine-N-oxide or compound 21 change behavior relevant to locomotion, exploration, anxiety, and depression in male non-DREADD-expressing mice?

This study investigates whether chronic systemic injections of DREADD agonists CNO or C21 alter behavior in non-DREADD-expressing mice, finding minimal behavioral effects.

Fibronectin receptor integrin α5β1 regulates assembly of PP2A complexes through PDE4D: modulation of vascular inflammation and atherosclerosis

This study shows that integrin α5β1 regulates PP2A complex assembly via PDE4D5, reducing vascular inflammation and atherosclerosis in mice.