NLRP3 activation in response to disrupted endocytic traffic
B. Lee, C. Hoyle, J. Green, R. Wellens, F. Martin-Sanchez, D. Williams, P. Seoane, H. Bennett, A. D. Adamson, G. Lopez-Castejon, M. Lowe, D. Brough
This study shows NLRP3 detects disrupted endosome trafficking, leading to inflammasome activation and cytokine release in macrophages.
bioRxiv · Sep 15, 2021Immunology