Author

F. Martin-Sanchez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

D. Brough· 3 shared G. Lopez-Castejon· 3 shared A. D. Adamson· 1 shared A. Gritsenko· 1 shared A. I. Gomez-Sanchez· 1 shared A. Tapia-Abellan· 1 shared B. Lee· 1 shared C. Hoyle· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

D. Brough

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pyroptosis leads to loss of centrosomal integrity in macrophages

S. Bai, F. Martin-Sanchez, D. Brough, G. Lopez-Castejon

This study shows that NLRP3 inflammasome activation in macrophages leads to loss of centrosomal scaffold protein PCNT, affecting centrosome structure and potentially contributing to inflammatory disease pathogenesis.

bioRxiv · Nov 22, 2023 · PreprintImmunology

NLRP3 activation in response to disrupted endocytic traffic

B. Lee, C. Hoyle, J. Green, R. Wellens, F. Martin-Sanchez, D. Williams, P. Seoane, H. Bennett, A. D. Adamson, G. Lopez-Castejon, M. Lowe, D. Brough

This study shows NLRP3 detects disrupted endosome trafficking, leading to inflammasome activation and cytokine release in macrophages.

bioRxiv · Sep 15, 2021Immunology

Priming Is Dispensable For NLRP3 Inflammasome Activation In Human Monocytes

A. Gritsenko, S. Yu, F. Martin-Sanchez, I. Diaz del Olmo, E.-M. Nichols, D. M. Davis, D. Brough, G. Lopez-Castejon

This study shows that the priming step is not required for NLRP3 inflammasome activation in human monocytes, as nigericin and IL-37 can trigger caspase-1 activation and cytokine release without prior priming.

bioRxiv · Jan 30, 2020Immunology

ASC oligomer favor caspase-1CARD domain recruitment after intracellular potassium efflux

F. Martin-Sanchez, V. Compan, A. Tapia-Abellan, A. I. Gomez-Sanchez, M. C. Banos, F. I. Schmidt, P. Pelegrin

The paper shows that ASC oligomers change structure with low intracellular K+ to enhance caspase-1 recruitment, independent of NLRP3, and highlights K+ homeostasis as a key regulator of inflammasome activity.

bioRxiv · Jan 27, 2020Immunology