Author

C. Hoyle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Organism:multiple species· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Brough· 3 shared G. Lopez-Castejon· 2 shared H. Bennett· 2 shared J. P. Green· 2 shared R. Wellens· 2 shared A. Adamson· 1 shared A. D. Adamson· 1 shared B. Lee· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersImmunology

D. Brough

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3 papers

Recent·Most cited

Proximity labelling and evolutionary evidence reveal insights into IL-1α nuclear networks and function

R. Wellens, V. S. Tapia, H. Bennett, A. Adamson, J. Rivers-Auty, J. P. Green, G. Lopez-Castejon, D. Brough, C. Hoyle

The paper investigates the nuclear role of pro-IL-1 and evolutionary changes in its NLS and HAT-binding domains using proximity labelling and mutation analysis.

bioRxiv · Jun 26, 2023Immunology

NLRP3 activation in response to disrupted endocytic traffic

B. Lee, C. Hoyle, J. Green, R. Wellens, F. Martin-Sanchez, D. Williams, P. Seoane, H. Bennett, A. D. Adamson, G. Lopez-Castejon, M. Lowe, D. Brough

This study shows NLRP3 detects disrupted endosome trafficking, leading to inflammasome activation and cytokine release in macrophages.

bioRxiv · Sep 15, 2021Immunology

Itaconate and fumarate derivatives exert a dual inhibitory effect on canonical NLRP3 activation in macrophages and microglia

C. Hoyle, J. P. Green, S. M. Allan, D. Brough, E. Lemarchand

This study shows itaconate and fumarate derivatives inhibit both priming and activation of NLRP3 inflammasome in macrophages and microglia, suggesting their therapeutic potential for NLRP3-driven diseases.

bioRxiv · Feb 1, 2021Immunology