Trinucleotide mRNA cap analog N6-benzylated at the site of posttranscriptional m6Am mark facilitates mRNA purification and confers superior translational properties in vitro and in vivo
M. Warminski, E. Trepkowska, M. Smietanski, P. J. Sikorski, M. R. Baranowski, M. Bednarczyk, H. Kedzierska, B. Majewski, A. Mamot, D. Papiernik, A. Popielec, R. Serwa, B. A. Shimanski, P. Sklepkiewicz, M. Sklucka, , J. Kowalska
This paper introduces a modified mRNA cap analog, AvantCap, which improves mRNA purification and translational efficiency in vitro and in vivo.
bioRxiv · Nov 10, 2023 · PreprintBiochemistry