Author

J. Kowalska

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Immunology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:protein folding & dynamics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Assay:proteomics· 2

Frequent Co-Authors

J. Jemielity· 6 shared M. Warminski· 5 shared D. Nowis· 3 shared P. J. Sikorski· 3 shared T. Spiewla· 3 shared A. Depaix· 2 shared J. Golab· 2 shared K. Grab· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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6 shared papersBiochemistry

J. Jemielity

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

An MST-based assay reveals new binding preferences of IFIT1 for canonically and non-canonically capped RNAs

T. Spiewla, K. Grab, A. Depaix, K. Ziemkiewicz, M. Warminski, J. Jemielity, J. Kowalska

This study develops an MST-based assay to assess IFIT1 binding to various capped RNAs, revealing new preferences for canonical and non-canonical RNA caps.

bioRxiv · May 10, 2024Biochemistry

Trinucleotide mRNA cap analog N6-benzylated at the site of posttranscriptional m6Am mark facilitates mRNA purification and confers superior translational properties in vitro and in vivo

M. Warminski, E. Trepkowska, M. Smietanski, P. J. Sikorski, M. R. Baranowski, M. Bednarczyk, H. Kedzierska, B. Majewski, A. Mamot, D. Papiernik, A. Popielec, R. Serwa, B. A. Shimanski, P. Sklepkiewicz, M. Sklucka, , J. Kowalska

This paper introduces a modified mRNA cap analog, AvantCap, which improves mRNA purification and translational efficiency in vitro and in vivo.

bioRxiv · Nov 10, 2023 · PreprintBiochemistry

Extracellular diadenosine tetraphosphate (Ap4A) is recognized by the plasma membrane purinoreceptor P2K1/DORN1 and closes stomata in Arabidopsis thaliana

J. Dobrogojski, V.-H. Nguyen, J. Kowalska, S. Borek, M. Pietrowska-Borek

The paper shows that Ap4A is recognized by P2K1/DORN1 in Arabidopsis, triggering stomatal closure and transcriptional changes, while Cp4C has opposing effects.

bioRxiv · May 10, 2023 · PreprintPlant Biology

SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune response

P. S. Krawczyk, O. Gewartowska, M. Mazur, W. Orzel, K. Matylla-Kulinska, S. Jelen, P. Turowski, T. Spiewla, B. Tarkowski, A. Tudek, A. Brouze, A. Wesolowska, D. Nowis, J. Golab, J. Kowalska, , S. Mroczek

This study shows that SARS-CoV-2 mRNA vaccines are re-adenylated in vivo, increasing antigen production and immune response in macrophages.

bioRxiv · Dec 1, 2022 · PreprintImmunology

HIV-1 infection reduces NAD capping of host cell snRNA and snoRNA

B. Benoni, J. F. Potuznik, A. Skriba, R. Benoni, J. Trylcova, M. Tulpa, K. Spustova, K. Grab, M.-B. Mititelu, J. Paces, J. Weber, D. Stanek, J. Kowalska, L. Bednarova, Z. Keckesova, , H. Cahova

This study shows HIV-1 infection reduces NAD capping of host snRNA and snoRNA, leading to increased HIV-1 infectivity by destabilizing RNA duplexes.

bioRxiv · Nov 10, 2022Biochemistry

2'-O -methylation of the second transcribed nucleotide within mRNA 5' cap impacts protein production level in a cell specific manner and contributes to RNA immune evasion

K. Drazkowska, N. Baran, M. Warminski, R. Tomecki, A. Depaix, D. Cysewski, R. Kasprzyk, J. Kowalska, J. Jemielity, P. J. Sikorski

This study shows that 2'-O-methylation of the second transcribed nucleotide in mRNA 5' cap affects protein production levels and contributes to RNA immune evasion in a cell-specific manner.

bioRxiv · Feb 3, 2022Biochemistry

Functional and LC-MS/MS analysis of in vitro transcribed mRNAs carrying phosphorothioate or boranophosphate moieties reveal polyA tail modifications that prevent deadenylation without compromising protein expression

D. Strzelecka, M. Smietanski, P. Sikorski, M. Warminski, J. Kowalska, J. Jemielity

This study examines how phosphorothioate and boranophosphate modifications in mRNA polyA tails affect deadenylation resistance and protein expression.

bioRxiv · Jul 2, 2020 · PreprintBiochemistry

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells

P. J. Sikorski, M. Warminski, D. Kubacka, T. Ratajczak, D. Nowis, J. Kowalska, J. Jemielity

bioRxiv · Nov 25, 2019Biochemistry