Author

P. Sportoletti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. Marra· 2 shared A. Gagliardi· 1 shared A. Khanna-Gupta· 1 shared B. Bigerna· 1 shared B. Falini· 1 shared C. Quintarelli· 1 shared D. Nachmani· 1 shared F. Locatelli· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

A. Marra

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Prolonged XPO1 inhibition is essential for optimal anti-leukemic activity in NPM1-mutated AML

G. Pianigiani, A. Gagliardi, F. Mezzasoma, F. Rocchio, V. Tini, B. Bigerna, P. Sportoletti, S. Caruso, A. Marra, G. Spinozzi, S. Shacham, Y. Landesman, C. Quintarelli, F. Locatelli, M. P. Martelli, , L. Brunetti

This study shows that prolonged XPO1 inhibition is more effective than intermittent dosing in NPM1-mutated AML by achieving stable HOX downregulation and anti-leukemic activity.

bioRxiv · Dec 11, 2021 · PreprintCancer Biology

Macrophage Function is Regulated by NPM1-Mediated 2'-O-Methylation

P. Sportoletti, D. Nachmani, L. Riccardi, A. Khanna-Gupta, J. Chen, A. Marra, N. Berliner, J. G. Clohessy, P. P. Pandolfi

This study shows that NPM1 regulates macrophage function through rRNA 2'-O-methylation and translation control, revealing a role in immune cell activity.

bioRxiv · Apr 18, 2020 · PreprintCell Biology