Author

P. P. Pandolfi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. G. Clohessy· 2 shared A. C. Liu· 1 shared A. Carracedo· 1 shared A. Di Ruscio· 1 shared A. Jha· 1 shared A. K. Ebralidze· 1 shared A. Khanna-Gupta· 1 shared A. Marra· 1 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

J. G. Clohessy

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Author profile →

5 papers

Recent·Most cited

Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma

S. M. Davidson, J. E. Heyman, J. P. O'Brien, A. C. Liu, D. R. Schmidt, W. J. Israelsen, T. L. Dayton, R. Sehgal, R. Bronson, E. Freinkman, H. Mak, S. Malstrom, G. Bellinger, A. Carracedo, P. P. Pandolfi, , M. G. Vander Heiden

The paper investigates the role of pyruvate kinase isoforms in prostate cancer, finding that Pkm1 suppresses cancer while Pkm2 promotes it, and that a PKM1-like activator can suppress tumor progression.

bioRxiv · May 9, 2021Cancer Biology

Myeloid lncRNA LOUP Mediates Opposing Regulatory Effects of RUNX1 and RUNX1-ETO in t(8;21) AML

B. Q. Trinh, S. Ummarino, A. K. Ebralidze, E. van der Kouwe, M. A. Bassal, T. M. Nguyen, R. Coffey, D. E. Tenen, E. Fabiani, C. Gurnari, C.-S. Wu, V. E. Angarica, Y. Zhang, L. Ying, H. Yang, , D. G. Tenen

The paper identifies the long noncoding RNA LOUP as a mediator of RUNX1 and RUNX1-ETO effects in t(8;21) AML, showing it promotes myeloid differentiation and inhibits cell growth by regulating PU.1 expression.

bioRxiv · Jul 24, 2020Cancer Biology

Synthetic antibodies neutralize SARS-CoV-2 infection of mammalian cells

S. Miersch, M. Ustav, Z. Li, J. B. Case, S. Ganaie, G. Matusali, F. Colavita, D. Lapa, M. R. Capobianchi, G. Novelli, J. B. Gupta, S. Jain, P. P. Pandolfi, M. S. Diamond, G. Amarasinghe, , S. S. Sidhu

The paper describes synthetic monoclonal antibodies that neutralize SARS-CoV-2 by binding to the spike protein and blocking ACE2 receptor interaction, showing potent antiviral activity.

bioRxiv · Jun 5, 2020 · PreprintBiochemistry

Macrophage Function is Regulated by NPM1-Mediated 2'-O-Methylation

P. Sportoletti, D. Nachmani, L. Riccardi, A. Khanna-Gupta, J. Chen, A. Marra, N. Berliner, J. G. Clohessy, P. P. Pandolfi

This study shows that NPM1 regulates macrophage function through rRNA 2'-O-methylation and translation control, revealing a role in immune cell activity.

bioRxiv · Apr 18, 2020 · PreprintCell Biology

Hematopoietic p53 loss cell-extrinsically defines an immune infiltrated microenvironment in leukemia and pre-leukemia

R. R. Posey, J. D. Lee, J. G. Clohessy, L. M. Mendez, P. P. Pandolfi

This study shows that loss of hematopoietic p53 leads to immune infiltration in leukemia and pre-leukemia, suggesting immunotherapy potential for TP53-mutated AML.

bioRxiv · Mar 22, 2020 · PreprintCancer Biology