Cell BiologybioRxiv
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
T. A. M. Chessa, P. Jung, S. Suire…·L. R. Stephens
The paper identifies PLEKHS1 as a driver of PI3K activity in PTEN-null prostate tissue, showing it bypasses feedback mechanisms to promote tumour progression.