TIRAP drives myelosuppression through an Ifnγ-Hmgb1 axis that disrupts the marrow microenvironment
R. Ibrahim, A. Gopal, M. Fuller, P. Umlandt, L. Chang, J. Wegrzyn-Woltosz, J. Lam, J. Li, M. Lu, J. Parker, A. Karsan
This paper identifies TIRAP as a driver of myelosuppression through an Ifnγ-Hmgb1 axis that disrupts the bone marrow microenvironment, independent of T cell function or pyroptosis.
bioRxiv · Feb 26, 2020Cancer Biology