J. Parker

Graph-based modeling of multiparametric MRI deciphers molecular states of high-grade glioma invasion with prognostic implications

This paper uses graph-based modeling of multiparametric MRI to identify molecular states in high-grade glioma and shows their prognostic significance.

The genomic and cellular basis of biosynthetic innovation in rove beetles

This study investigates the genomic and cellular basis of biosynthetic innovation in rove beetles, identifying key genomic and cellular mechanisms underlying the evolution of defensive secretions.

Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the Mucor species complex

This study identifies Erg3 and Erg6a as key enzymes in the ergosterol biosynthetic pathway of Mucor circinelloides, showing their roles in antifungal drug resistance and virulence.

Sexual antagonism and sex determination in three syngnathid species alongside male pregnancy gradient and varying sex roles.

This study investigates the link between sexual antagonism and sex determination in three syngnathid species, finding that sex roles and mate competition drive sexual antagonism rather than male pregnancy.

The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species.

This paper identifies Erg6 as an essential gene for viability in Aspergillus species and shows its importance in fungal infection models.

Tunnelling nanotubules are druggable mediators of cancer-niche crosstalk.

This paper develops a prototype bone marrow-like extracellular matrix and shows that tunnelling nanotubes between leukemia cells and mesenchymal stromal cells are druggable, leading to a triple drug combination with high efficacy.

Piezo inhibition prevents and rescues scarring by targeting the adipocyte to fibroblast transition

This study shows that inhibiting Piezo1 or Piezo2 prevents adipocyte-to-fibroblast transition, reducing scarring in wounds and suggesting a therapeutic target for fibrosis.

A human mesenchymal spheroid prototype to replace moderate severity animal procedures in leukaemia drug testing

This paper develops a human mesenchymal spheroid platform to replace animal testing in leukemia drug testing, showing faster results and better modeling of treatment resistance.

Loss of FBXO11 function establishes a stem cell program in acute myeloid leukemia through dysregulation of the mitochondrial LONP1

This study identifies FBXO11 loss as a driver of AML by promoting a stem cell program through mitochondrial dysregulation.

Human iPSC-Vascular Smooth Muscle Cell Spheroids Demonstrate Size-dependent Alterations in Cellular Viability and Secretory Function

This study investigates how the size of hiPSC-VSMC spheroids affects cell viability and paracrine secretion, finding that 10,000 cells optimizes both.

Loss-of-function ROX1 mutations suppress the fluconazole susceptibility of upc2AΔ mutation in Candida glabrata, implicating additional positive regulators of ergosterol biosynthesis

The paper identifies ROX1 as a negative regulator of ergosterol biosynthesis genes in C. glabrata and shows that its loss-of-function suppresses fluconazole hypersusceptibility in upc2AΔ mutants.

Large-scale comparative genomics unravels great genomic diversity across the Rickettsia and Ca. Megaira genera and identifies Torix group as an evolutionarily distinct clade.

This paper presents new genomes of Rickettsia and Ca. Megaira, identifies Torix as a distinct clade, and proposes a new genus name for it.

Structure of an ant-myrmecophile-microbe community

The paper characterizes the microbiota of ant-myrmecophile systems, finding that microbial communities reflect behavioral interactions and evolve independently of deep evolutionary history.

Optimal dynamic incentive scheduling for Hawk-Dove evolutionary games

This paper develops optimal dynamic incentive schedules for Hawk-Dove evolutionary games to maximize or minimize aggressive population frequency over time.

Evolutionary assembly of cooperating cell types in an animal chemical defense system

The paper shows how two cooperating cell types in a rove beetle gland evolved to produce a defensive chemical cocktail through coevolution and functional integration.

Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors.

This study identifies transcription factors regulating HIV latency through epigenomic analysis of latently infected cells.

Reovirus σ3 protein limits interferon expression and cell death induction

This study shows that reovirus σ3 protein reduces interferon production and necroptosis by mechanisms unrelated to its dsRNA binding ability.

YY1 cistrome analysis uncovers an essential requirement of the YY1:BRD4-PFKP regulatory axis for promoting tumorigenesis of castration-resistant prostate cancer

This study identifies a YY1:BRD4-PFKP regulatory axis critical for castration-resistant prostate cancer tumorigenesis through cistrome analysis and functional experiments.

Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells

The paper identifies HLA-II-bound peptides from SARS-CoV-2 spike protein presented by dendritic cells, revealing glycan trimming and a receptor-binding motif-rich region for vaccine design.

Rapid Parallel Adaptation to Anthropogenic Heavy Metal Pollution

This study shows that Silene uniflora rapidly adapted to zinc-contaminated soils without gene flow, revealing complex genetic responses to anthropogenic pollution.

TIRAP drives myelosuppression through an Ifnγ-Hmgb1 axis that disrupts the marrow microenvironment

This paper identifies TIRAP as a driver of myelosuppression through an Ifnγ-Hmgb1 axis that disrupts the bone marrow microenvironment, independent of T cell function or pyroptosis.

Mutations in TAC1B: a novel genetic determinant of clinical fluconazole resistance in C. auris

This paper identifies mutations in TAC1B as a novel genetic determinant of clinical fluconazole resistance in C. auris, showing their contribution to resistance through increased CDR1 expression and functional validation.

Comparative genomics for the elucidation of multidrug resistance (MDR) in Candida lusitaniae

This paper identifies six non-synonymous SNPs associated with multidrug resistance in Candida lusitaniae through comparative genomics and functional validation.

A framework for predicting soft-fruit yields and phenology using embedded, networked microsensors, coupled weather models and machine-learning techniques

This paper develops a framework using microsensors, weather models, and machine learning to predict soft fruit yields and phenology with higher accuracy.

Deep-time convergence in rove beetle symbionts of army ants

The paper shows that myrmecoid rove beetles have evolved independently multiple times, each adapting to specific army ant hosts in different regions over millions of years.