Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth.
S. L. Geeraerts, K. R. Kampen, G. Rinaldi, P. Gupta, M. Planque, K. De Cremer, K. De Brucker, S. Vereecke, B. Verbelen, P. Vermeersch, D. Cassiman, S.-M. Fendt, A. Voet, B. P. A. Cammue, K. Thevissen, K. De Keersmaecker
This study repurposes sertraline as an inhibitor of serine hydroxymethyltransferase to target serine/glycine synthesis in breast cancer, showing synergistic antitumor effects with mitochondrial inhibitors.
bioRxiv · Jun 12, 2020Cancer Biology