D. Cassiman

Integrating multiple omics levels using the human protein complexome as a framework, a multi-omics study of inborn errors of metabolism

This study integrates proteomics, transcriptomics, and metabolomics data from IEM patients to identify perturbed protein complexes and pathways, highlighting mitochondrial oxidative phosphorylation and histone acetylation dysregulation.

Human ADA2 deficiency is characterized by the absence of an intracellular hypoglycosylated form of adenosine deaminase 2

The paper identifies an intracellular hypoglycosylated form of ADA2 absent in DADA2 patients, linking its absence to reduced deaminase activity and variant pathogenicity.

Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth.

This study repurposes sertraline as an inhibitor of serine hydroxymethyltransferase to target serine/glycine synthesis in breast cancer, showing synergistic antitumor effects with mitochondrial inhibitors.