G. Rinaldi

A drug repurposing screen for whipworms informed by comparative genomics

This paper identifies potential anti-whipworm drugs by testing approved human drugs ex vivo and in vivo, finding limited efficacy due to pharmacokinetic challenges.

Nucleated Fish Erythrocyte Extracellular Traps (FEETs) release is an evolutionary conserved immune defence process

This study shows fish erythrocytes can release extracellular traps (FEETs) similar to NETosis, revealing a new immune function in nucleated erythrocytes.

Heterogeneity in PHGDH protein expression potentiates cancer cell dissemination and metastasis

This study identifies PHGDH protein expression heterogeneity as a driver of breast cancer metastasis by altering metabolic pathways and promoting dissemination.

Tumor Necrosis Factor and Schistosoma mansoni egg antigen Omega-1 shape distinct aspects of the early egg-induced granulomatous response

This study investigates how TNF and omega-1 from Schistosoma mansoni eggs influence granuloma formation in zebrafish, showing distinct roles in macrophage recruitment and granuloma enlargement.

Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth.

This study repurposes sertraline as an inhibitor of serine hydroxymethyltransferase to target serine/glycine synthesis in breast cancer, showing synergistic antitumor effects with mitochondrial inhibitors.

Transcriptome of the parasitic flatworm Schistosoma mansoni during intra-mammalian development

This study analyzes RNA-seq data from Schistosoma mansoni during intra-mammalian development, identifying genes involved in immune evasion and adaptation to oxidative stress.

Schistosoma mansoni eggs modulate the timing of granuloma formation to promote transmission

This study shows that Schistosoma mansoni eggs modulate granuloma formation timing to promote parasite transmission by evading immune response until optimal extrusion.

Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

The paper compares metabolite profiles of liver flukes to investigate carcinogenic potential, finding differences in oxysterol-like metabolites between carcinogenic and non-carcinogenic species.

A library of cell-surface and secreted proteins from Schistosoma mansoni identifies early serological markers of infection

The paper identifies early serological markers of Schistosoma mansoni infection using a recombinant protein library and mouse infection time series.