Author

K. De Keersmaecker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

A. Bridgeman· 1 shared A. Chabes· 1 shared A. Schuh· 1 shared A. Voet· 1 shared B. Dadonaite· 1 shared B. P. A. Cammue· 1 shared B. Verbelen· 1 shared C. Cursi· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

A. Bridgeman

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2 papers

Recent·Most cited

Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth.

S. L. Geeraerts, K. R. Kampen, G. Rinaldi, P. Gupta, M. Planque, K. De Cremer, K. De Brucker, S. Vereecke, B. Verbelen, P. Vermeersch, D. Cassiman, S.-M. Fendt, A. Voet, B. P. A. Cammue, K. Thevissen, K. De Keersmaecker

This study repurposes sertraline as an inhibitor of serine hydroxymethyltransferase to target serine/glycine synthesis in breast cancer, showing synergistic antitumor effects with mitochondrial inhibitors.

bioRxiv · Jun 12, 2020Cancer Biology

SAMHD1 limits the efficacy of forodesine in leukaemia by protecting cells against cytotoxicity of dGTP

T. Davenne, J. Klintman, S. Sharma, R. E. Rigby, C. Cursi, A. Bridgeman, B. Dadonaite, K. De Keersmaecker, P. Hillmen, A. Chabes, A. Schuh, J. Rehwinkel

This paper shows that SAMHD1 protects cells from dGTP toxicity caused by forodesine, and that forodesine can selectively kill SAMHD1-deficient leukemia cells.

bioRxiv · Feb 17, 2020Cancer Biology