Hypoxia-induced SETX links replication stress with the unfolded protein response
S. Ramachandran, T. Ma, N. Ng, I. Foskolou, M.-S. Hwang, P. Victori, W.-C. Cheng, F. M. Buffa, K. Leszczynska, N. Gromak, E. M. Hammond
This study shows hypoxia induces SETX, which protects cells from DNA damage by linking replication stress and the unfolded protein response.
bioRxiv · May 24, 2020Cancer Biology