Quantifying the heterogeneity of macromolecular machines by mass photometry
A. Sonn Segev, K. Belacic, T. Bodrug, G. Young, R. T. VanderLinden, B. Schulman, J. Schimpf, T. Friedrich, P. Vinh Dip, T. Schwartz, B. Bauer, J.-M. Peters, W. B. Struwe, J. L. Benesch, N. G. Brown, , P. Kukura
This paper demonstrates that mass photometry accurately quantifies sample heterogeneity with high resolution and minimal volume, outperforming negative stain electron microscopy in detecting proteasome assemblies.
bioRxiv · Dec 4, 2019Biophysics