Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
D. Y. Nie, J. R. Tabor, J. Li, M. Kutera, J. St-Germain, R. P. Hanley, E. Z. WOLF, E. Paulakonis, T. M. G. Kenney, S. Duan, S. Shrestha, D. D. Owens, A. Pon, M. Szewczyk, A. J. Lamberto, , C. Arrowsmith
This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.
bioRxiv · Nov 1, 2023Biochemistry
R. D. Mouery, C. Hsu, T. Bonacci, D. L. Bolhuis, X. Wang, C. A. Mills, E. D. Toomer, O. G. Canterbury, K. C. Robertson, T. B. Branigan, N. G. Brown, L. E. Herring, M. Emanuele
The paper uses proteomics and PLK1 inhibition to identify proteins degraded at G2/M, showing PLK1's role in coordinating proteolysis via SCF ligases and linking AKAP2 to cell cycle control.
bioRxiv · Oct 11, 2023 · PreprintCell Biology
L. E. McCormick, C. Suarez, L. E. Herring, K. S. Cannon, D. R. Kovar, N. G. Brown, S. L. Gupton
This study shows that multi-monoubiquitination of VASP at specific lysine residues negatively regulates its actin-binding and bundling activities, affecting cell spreading morphology.
bioRxiv · Jul 16, 2023Cell Biology
Z. Hodakova, I. Grishkovskaya, H. L. Brunner, D. L. Bolhuis, K. Belacic, A. Schleiffer, H. Kotisch, N. G. Brown, D. Haselbach
The paper presents the cryo-EM structure of UBR5, revealing its dimeric architecture and dynamic domain movements, and identifies AKIRIN2 as an interacting protein.
bioRxiv · Nov 3, 2022 · PreprintBiochemistry
T. P. Enrico, W. Stallaert, E. T. Wick, P. Ngoi, S. M. Rubin, N. G. Brown, J. E. Purvis, M. J. Emanuele
This study identifies cyclin F as a regulator of p130/RBL2 degradation via SCF, showing its role in cell cycle control and potential implications in cancer.
bioRxiv · Apr 23, 2021Cell Biology
J. Kernan, R. C. Martinez-Chacin, X. Wang, R. L. Tiedemann, T. Bonacci, R. Choudhury, D. Bolhuis, J. S. Damrauer, F. Yan, J. S. Harrison, M. B. Major, K. Hoadley, A. Suzuki, S. B. Rothbart, N. G. Brown, M. J. Emanuele
The paper predicts APC/C substrates in silico, identifies chromatin regulators as substrates, and shows their cell cycle-dependent degradation and impact on DNA methylation.
bioRxiv · Apr 9, 2020Cell Biology
A. Sonn Segev, K. Belacic, T. Bodrug, G. Young, R. T. VanderLinden, B. Schulman, J. Schimpf, T. Friedrich, P. Vinh Dip, T. Schwartz, B. Bauer, J.-M. Peters, W. B. Struwe, J. L. Benesch, N. G. Brown, , P. Kukura
This paper demonstrates that mass photometry accurately quantifies sample heterogeneity with high resolution and minimal volume, outperforming negative stain electron microscopy in detecting proteasome assemblies.
bioRxiv · Dec 4, 2019Biophysics
E. R. Watson, C. R. R. Grace, W. Zhang, D. J. Miller, I. F. Davidson, J. R. Prabu, S. Yu, D. L. Bolhuis, E. T. Kulko, R. Vollrath, D. Haselbach, H. Stark, J.-M. Peters, N. G. Brown, S. S. Sidhu, B. A. Schulman
The paper identifies a cryptic ubiquitin-binding site on APC/C using ubiquitin variants, revealing its preference for K48-linked chains and demonstrating a method for uncovering such sites in large complexes.
bioRxiv · Jun 12, 2019 · PreprintBiochemistry