Smooth muscle-specific MMP17 (MT4-MMP) defines the intestinal ECM niche
M. Martin-Alonso, H. Lindholm, S. Iqbal, P. Vornewald, S. Hoel, M. Damen, A. F. M. Altelaar, P. Katajisto, A. G. Arroyo, M. J. Oudhoff
The paper identifies MMP17 as a smooth muscle-specific factor critical for intestinal epithelial repair and stem cell niche regulation through its cleavage of PERIOSTIN and activation of YAP.
bioRxiv · Jun 18, 2020Cell Biology