P. Katajisto

Ribosome-binding protein 1, RRBP1, maintains peroxisomal biogenesis

This study identifies RRBP1 as a novel peroxisome biogenesis factor in human cells, showing it promotes peroxisome formation and stabilizes peroxisomal proteins.

Inheritance of old mitochondria controls early CD8+ T cell fate commitment and is regulated by autophagy

This study shows that autophagy regulates asymmetric inheritance of old mitochondria in CD8+ T cells, which influences their metabolic state and memory potential.

The α-dystroglycan N-terminus is a broad-spectrum antiviral agent against SARS-CoV-2 and enveloped viruses

This study shows that the N-terminal fragment of α-dystroglycan blocks SARS-CoV-2 and other enveloped viruses in cell culture and animal models.

Golgi organization is a determinant of stem cell function in the small intestine

This study shows that Lgr5+ stem cells in the small intestine adjust their Golgi apparatus orientation to enhance niche signal reception and tissue regeneration, which is impaired with age.

Shared requirement for MYC upstream super-enhancer region in tissue regeneration and cancer

The paper identifies a shared genomic region upstream of Myc that is critical for both intestinal regeneration and cancer, revealing a genetic link between tissue renewal and tumorigenesis.

Reticular adhesion formation is mediated by flat clathrin lattices and opposed by fibrillar adhesions

The paper shows that flat clathrin lattices assemble reticular adhesions, which are opposed by fibrillar adhesions, revealing a novel interaction between endocytic and adhesion processes.

LAM - an image analysis method for regionally defined organ-wide cellular phenotyping of the Drosophila midgut

The paper introduces LAM, an imaging method to analyze regional cellular phenotypes in Drosophila midgut, revealing regional heterogeneity in ISC responses to colitis.

Smooth muscle-specific MMP17 (MT4-MMP) defines the intestinal ECM niche

The paper identifies MMP17 as a smooth muscle-specific factor critical for intestinal epithelial repair and stem cell niche regulation through its cleavage of PERIOSTIN and activation of YAP.

Laminin alpha 5 is Necessary for Mammary Epithelial Growth and Function by Maintaining Luminal Epithelial Cell Identity

This study shows that laminin alpha 5 is essential for mammary gland growth and function by maintaining luminal epithelial cell identity during development and remodeling.