Author

P. Y. Chew

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:protein sequence· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

R. Collepardo-Guevara· 3 shared A. Reinhardt· 2 shared J. A. Joseph· 2 shared A. Aguirre· 1 shared J. Rene Espinosa· 1 shared K. Brown· 1 shared S. Ingersoll· 1 shared T. Kutateladze· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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3 shared papersBiophysics

R. Collepardo-Guevara

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Aromatic and arginine content drives multiphasic condensation of protein-RNA mixtures

P. Y. Chew, J. A. Joseph, R. Collepardo-Guevara, A. Reinhardt

This study uses simulations to show that aromatic and arginine residues drive multiphasic condensation of protein-RNA mixtures, enabling design of synthetic condensates.

bioRxiv · Apr 5, 2023Biophysics

Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation

K. Brown, P. Y. Chew, S. Ingersoll, J. Rene Espinosa, A. Aguirre, T. Kutateladze, R. Collepardo-Guevara, X. Ren

This study reveals the scaffold-client model of PRC1 condensate assembly through phase separation, showing how CBX2 acts as a scaffold and other subunits influence condensate properties and composition.

bioRxiv · Dec 26, 2022Biochemistry

Designing multiphase biomolecular condensates by coevolution of protein mixtures

P. Y. Chew, J. A. Joseph, R. Collepardo-Guevara, A. Reinhardt

This study designs protein pairs that form multiphase biomolecular condensates using a computational method combining genetic algorithms and coarse-grained models.

bioRxiv · Apr 22, 2022Biophysics