Skin inflammation driven by differentiation of quiescent tissue-resident ILCs into a spectrum of pathogenic effectors
P. Bielecki, S. J. Riesenfeld, M. S. Kowalczyk, M. C. Amezcua Vesely, L. Kroehling, P. Yaghoubi, D. Dionne, A. Jarret, H. R. Steach, H. M. McGee, C. B. M. Porter, P. Licona-Limon, W. Bailis, R. Jackson, N. Gagliani, , R. A. Flavell
The paper shows that psoriasis is driven by the reprogramming of quiescent skin-resident ILCs into pathogenic effectors through epigenetic and transcriptional changes.
bioRxiv · Nov 12, 2018Immunology