R. Jackson

The meninges host a unique compartment of regulatory T cells that bulwarks adult hippocampal neurogenesis

The paper identifies a unique population of regulatory T cells in the murine meninges that maintain brain homeostasis by suppressing interferon-gamma-producing lymphocytes and preventing hippocampal damage.

Point mutations in Arf1 reveal cooperative effects of the N-terminal region and myristate for GTPase-activating protein catalytic activity

The paper investigates how point mutations in Arf1 affect its interaction with GAPs, revealing cooperative effects between the N-terminal region and myristate on catalytic activity.

Virome analysis of New Zealand's bats reveals cross-species viral transmission among the Coronaviridae

This study analyzes the viromes of New Zealand's bats to investigate cross-species viral transmission, finding evidence of alphacoronavirus jumps between species and a novel short-genome coronavirus.

Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC

This paper develops a targeted proteomics assay to quantify NRF2 pathway components and clinical biomarkers in HNSCC, identifying correlations between NRF2 activity, HPV infection, and immune markers.

Evidence of phylosymbiosis in Formica ants

The paper investigates whether phylogenetically related ant species have distinct and stable microbiomes, finding that microbial communities mirror host phylogeny, supporting phylosymbiosis.

Characterization of 3D organotypic epithelial tissues reveals tonsil-specific differences in tonic interferon signaling

The paper compares gene expression in 3D-cultured epithelial tissues from foreskin, cervix, and tonsil to identify tissue-specific molecular mechanisms and immune-related differences.

Compensatory mutations reducing the fitness cost of plasmid carriage occur in plant rhizosphere communities

The paper shows compensatory mutations reduce the fitness cost of plasmid carriage in Pseudomonas fluorescens in plant rhizosphere communities.

Plasmid manipulation of bacterial behaviour through translational regulatory crosstalk

This paper identifies RsmQ as a plasmid translational regulator that globally controls bacterial behavior by altering the proteome, leading to a switch from motile to sessile lifestyle.

Human neutrophil development and functionality are enabled in a humanized mouse model

This study develops a humanized mouse model, MISTRGGR, that supports the generation of functional human neutrophils in circulation and tissues, which respond to inflammatory and infectious challenges.

GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma

This study shows that low GATA4 and GATA6 expression in pancreatic ductal adenocarcinoma (PDAC) is linked to worse patient outcomes and loss of the classical tumor phenotype.

Co-evolutionary analysis suggests a role for TLR9 in papillomavirus restriction

This study identifies TLR9 as a pattern recognition receptor involved in detecting papillomaviruses and shows co-evolution between papillomaviruses and their hosts.

Vesicular Trafficking Permits Evasion of cGAS/STING Surveillance During Initial Human Papillomavirus Infection

This paper shows that HPV evades cGAS/STING surveillance through unique vesicular trafficking, preventing cytosolic DNA detection and IFN responses.

Activity of the GHRH Antagonist MIA602 and its Underlying Mechanisms of Action in sarcoidosis

This study investigates the anti-inflammatory effects of MIA602, a GHRH antagonist, in sarcoidosis by analyzing its impact on cytokine levels and cellular markers in vitro and in vivo.

Human papillomavirus type 16 sub-lineages and integration in cancer

The paper investigates HPV16 sub-lineages and integration in cancer using NGS data from clinical samples, finding variant-specific integration signatures related to hypoxia/energetics versus host immune abrogation and cancer pathways.

Human and mouse essentiality screens as a resource for disease gene discovery

The paper integrates gene essentiality data from human and mouse screens to classify genes into FUSIL categories, identifying developmental lethal genes associated with rare diseases.

Parallel evolution in the integration of a co-obligate aphid symbiosis

This study identifies three independent transitions to a co-obligate aphid symbiosis and shows a predictable sequence of metabolic and physical integration between symbionts.

The potentials and pitfalls of a human cervical organoid model including Langerhans cells

The paper describes a human cervical organoid model incorporating Langerhans cells and provides a detailed protocol for its use in research.

Connecting the legs with a spring improves human running economy

A spring connecting human legs improves running economy by 6.4% through a complex mechanism affecting both swing and stance phases of gait.

Skin inflammation driven by differentiation of quiescent tissue-resident ILCs into a spectrum of pathogenic effectors

The paper shows that psoriasis is driven by the reprogramming of quiescent skin-resident ILCs into pathogenic effectors through epigenetic and transcriptional changes.

Human Cervical Keratinocyte-Derived Monolayer and Organoid Cultures for Disease Modelling and Drug Screening

This study establishes a reproducible method to grow cervical keratinocytes into monolayer and organoid cultures from patient biopsies, enabling disease modeling and drug screening.