R. A. Flavell

IL-10 constrains sphingolipid metabolism via fatty acid desaturation to limit inflammation

This study shows IL-10 limits inflammation by restricting sphingolipid metabolism through fatty acid desaturation, with metabolic correction reducing inflammation in IL-10-deficient macrophages.

Autologous humanized PDX modeling for immuno-oncology recapitulates the human tumor microenvironment

This study develops an autologous humanized PDX model to study tumor-immune interactions and demonstrates its utility in preclinical testing by showing VEGF-A inhibition reduces tumor growth.

Human neutrophil development and functionality are enabled in a humanized mouse model

This study develops a humanized mouse model, MISTRGGR, that supports the generation of functional human neutrophils in circulation and tissues, which respond to inflammatory and infectious challenges.

HIV-1 Vpu restricts Fc-mediated effector functions in vivo

This study shows that HIV-1 Vpu reduces nnAb recognition and ADCC resistance, with nnAb Fc-effector functions dependent on Env's open conformation.

Inflammasome activation in infected macrophages drives COVID-19 pathology

This study shows SARS-CoV-2 infection of human macrophages drives COVID-19 pathology through inflammasome activation, leading to inflammation and pyroptosis, but also enabling viral release.

m6A modifications regulate intestinal immunity and rotavirus infection

This study shows that m6A modifications regulate intestinal immunity and rotavirus infection by modulating IRF7 and IFN expression through METTL3 in intestinal epithelial cells.

Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy

This study shows that MSR1 restricts Chikungunya virus infection by activating autophagy through interactions with ATG12 and the ATG5-ATG12-ATG16L1 complex.

The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis

This study shows that the Firre locus produces a trans-acting RNA involved in hematopoiesis and immune function, as demonstrated through genetic models and functional assays.

Skin inflammation driven by differentiation of quiescent tissue-resident ILCs into a spectrum of pathogenic effectors

The paper shows that psoriasis is driven by the reprogramming of quiescent skin-resident ILCs into pathogenic effectors through epigenetic and transcriptional changes.

Membrane-cytoskeleton mechanical feedback mediated by myosin-I controls phagocytic efficiency

The paper shows that myosin 1e and 1f are required for efficient phagocytosis by regulating adhesion turnover and actin dynamics during phagocytic cup closure.

A Highly Efficient and Faithful MDS Patient-Derived Xenotransplantation Model for Pre-Clinical Studies

This paper develops a novel MDS patient-derived xenotransplantation model in MISTRG mice that faithfully represents all MDS subtypes and enables effective drug testing.