L. Kroehling

Microbiota-instructed regulatory T cell differentiation is mediated by a distinct RORγt+ antigen presenting cell subset

This study identifies a distinct RORγt+ antigen presenting cell subset that mediates microbiota-driven regulatory T cell differentiation, revealing a mechanism for maintaining immune tolerance.

c-MAF dependent perivascular macrophages regulate diet induced metabolic syndrome

This study identifies c-MAF-dependent perivascular macrophages and shows their role in regulating metabolic syndrome through altered gene expression and vascular changes in response to high-fat diet.

RORα enforces stability of the T-helper-17 cell effector program

This study shows ROR is essential for maintaining Th17 cell effector function through cooperative binding with ROR{gamma}t to an enhancer element.

Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancy

This study shows that targeting Gpi1 selectively inhibits pathogenic Th17 cells in autoimmune diseases while sparing homeostatic Th17 cells.

VIP-producing enteric neurons interact with innate lymphoid cells to regulate feeding-dependent intestinal epithelial barrier functions

This study shows that VIP-producing enteric neurons interact with ILC3 to regulate intestinal barrier functions and nutrient absorption during feeding.

Serum Amyloid A Proteins Induce Pathogenic TH17 Cells and Promote Inflammatory Disease

This study shows serum amyloid A proteins drive pathogenic TH17 cell differentiation and promote inflammatory disease through STAT3-activating cytokines.

Skin inflammation driven by differentiation of quiescent tissue-resident ILCs into a spectrum of pathogenic effectors

The paper shows that psoriasis is driven by the reprogramming of quiescent skin-resident ILCs into pathogenic effectors through epigenetic and transcriptional changes.