Author

P.-Y. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5

Signature Assays, Organisms & Methods

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Assay:imaging· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Approach:microscopy & imaging analysis· 2 Organism:non-human primate· 1

Frequent Co-Authors

I. A. Sigal· 5 shared B. Yang· 4 shared S. Waxman· 3 shared Y. Hua· 3 shared A. Gogola· 1 shared A. L. Gogola· 1 shared A. P. Voorhees· 1 shared B. L. Brazile· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersBioengineering

I. A. Sigal

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5 papers

Recent·Most cited

Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues

P.-Y. Lee, H. Schilpp, N. Naylor, S. C. Watkins, B. Yang, I. A. Sigal

This paper introduces IPOLπ, an improved version of polarized light microscopy that enhances collagen orientation discrimination and imaging speed in ocular tissues.

Optics and Lasers in Engineering · Jul 1, 2023Peer-reviewedBioengineering

Direct measurements of collagen fiber recruitment in the posterior pole of the eye

P.-Y. Lee, G. Fryc, J. Gnalian, Y. Hua, S. Waxman, F. Zhong, B. Yang, I. A. Sigal

This paper directly measures collagen fiber recruitment in the peripapillary sclera and lamina cribrosa under stretch, finding sigmoidal recruitment curves with PPS recruiting faster and at lower stretch than LC.

bioRxiv · May 7, 2023Bioengineering

Stretch-Induced Uncrimping of Equatorial Sclera Collagen Bundles

N.-J. Jan, P.-Y. Lee, J. Wallace, M. Iasella, A. Gogola, I. A. Sigal

This study measures stretch-induced collagen uncrimping in sclera using polarized light microscopy and nonlinear mixed effect models, finding exponential waviness reduction with strain and sigmoidal recruitment with stretch.

bioRxiv · Sep 13, 2022Bioengineering

Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy

P.-Y. Lee, B. Yang, Y. Hua, S. Waxman, Z. Zhu, F. Ji, I. A. Sigal

This paper demonstrates that instant polarized light microscopy (IPOL) can visualize and quantify collagen morphology and architecture changes in the optic nerve head under dynamic loading.

bioRxiv · Oct 3, 2021Bioengineering

Lamina cribrosa vessel and collagen beam networks are distinct

S. Waxman, B. L. Brazile, B. Yang, A. L. Gogola, Y. Hua, P. Lam, P.-Y. Lee, A. P. Voorhees, J. F. Rizzo, T. C. Jakobs, I. A. Sigal

The paper quantifies the spatial relationship between vascular and collagen networks in monkey lamina cribrosa, finding they are distinct with most beams lacking vessels and many vessels outside beams.

bioRxiv · Oct 3, 2021Bioengineering