I. A. Sigal

Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues

This paper introduces IPOLπ, an improved version of polarized light microscopy that enhances collagen orientation discrimination and imaging speed in ocular tissues.

Fibrous Finite Element Modeling of the Optic Nerve Head Region

This paper introduces a fibrous finite element model of the optic nerve head that incorporates histology-based collagen fiber organization to study biomechanics and microstructural mechanisms.

Direct measurements of collagen fiber recruitment in the posterior pole of the eye

This paper directly measures collagen fiber recruitment in the peripapillary sclera and lamina cribrosa under stretch, finding sigmoidal recruitment curves with PPS recruiting faster and at lower stretch than LC.

Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell

This study quantifies regional collagen fiber recruitment in the corneoscleral shell under intraocular pressure, showing significant variation in recruitment and fiber reserve across regions.

Individual Astrocyte Morphology in the Collagenous Lamina Cribrosa Revealed by Multicolor DiOlistic Labeling

This paper evaluates Multicolor DiOlistic labeling (MuDi) to reveal detailed morphology of collagenous lamina cribrosa astrocytes in non-human primates and other species.

Predatory Bacteria can Reduce Pseudomonas aeruginosa Induced Corneal Perforation and Proliferation in a Rabbit Keratitis Model

In vivo Modulation of Intraocular and Intracranial Pressures Causes Nonlinear and Non-monotonic Deformations of the Lamina Cribrosa and Scleral Canal

This study examines how changes in intraocular and intracranial pressures affect monkey optic nerve head morphology, finding nonlinear and non-monotonic deformations not explained by translaminar pressure difference.

A direct fiber approach to model sclera collagen architecture and biomechanics

This paper introduces a direct fiber modeling approach to accurately represent sclera collagen microstructure and mechanics, showing it captures both fiber-level interactions and macroscale behavior better than conventional continuum models.

Comparing acute IOP-induced lamina cribrosa deformations pre-mortem and post-mortem

The paper compares acute IOP-induced lamina cribrosa deformations in monkeys pre-mortem and post-mortem, finding similar trends but smaller pre-mortem deformations overall with local variations.

Stretch-Induced Uncrimping of Equatorial Sclera Collagen Bundles

This study measures stretch-induced collagen uncrimping in sclera using polarized light microscopy and nonlinear mixed effect models, finding exponential waviness reduction with strain and sigmoidal recruitment with stretch.

Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy

This paper demonstrates that instant polarized light microscopy (IPOL) can visualize and quantify collagen morphology and architecture changes in the optic nerve head under dynamic loading.

Lamina cribrosa vessel and collagen beam networks are distinct

The paper quantifies the spatial relationship between vascular and collagen networks in monkey lamina cribrosa, finding they are distinct with most beams lacking vessels and many vessels outside beams.

A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography

This paper introduces a high-accuracy and high-efficiency digital volume correlation method to analyze in-vivo optic nerve head biomechanics from OCT data, showing improved performance over conventional methods.

Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo

This study measures how changes in intraocular and intracranial pressure affect the optic nerve head in monkeys using OCT, showing significant interactions between the pressures.