Y. Hua

An optimized somatic embryo transformation system assisted homozygous edited rubber tree generation method mediated by CRISPR/Cas9

This study develops a CRISPR/Cas9-based method to generate homozygous edited rubber tree plants by optimizing somatic embryo transformation and subculture procedures.

Fibrous Finite Element Modeling of the Optic Nerve Head Region

This paper introduces a fibrous finite element model of the optic nerve head that incorporates histology-based collagen fiber organization to study biomechanics and microstructural mechanisms.

Direct measurements of collagen fiber recruitment in the posterior pole of the eye

This paper directly measures collagen fiber recruitment in the peripapillary sclera and lamina cribrosa under stretch, finding sigmoidal recruitment curves with PPS recruiting faster and at lower stretch than LC.

Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell

This study quantifies regional collagen fiber recruitment in the corneoscleral shell under intraocular pressure, showing significant variation in recruitment and fiber reserve across regions.

TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA

This study shows that autophagy in tumor endothelial cells suppresses antitumor immunity in melanoma by promoting an immunosuppressive phenotype, and its inhibition enhances T cell infiltration and restricts tumor growth.

HCC-1 accelerates atherosclerosis by inducing endothelial cells and macrophages pyroptosis and serves as an early diagnostic biomarker

This study shows HCC-1 promotes atherosclerosis by inducing pyroptosis in endothelial cells and macrophages and suggests it as an early diagnostic biomarker.

Single-cell Transcriptomic Analysis of Systemic Autoinflammatory Diseases with Anti-TNFα Therapy

This study uses single-cell RNA sequencing to analyze PBMCs and PMNs in SAIDs patients before and after anti-TNF therapy, revealing interferon responses in disease activity and unexpected cytokine elevation post-treatment.

A direct fiber approach to model sclera collagen architecture and biomechanics

This paper introduces a direct fiber modeling approach to accurately represent sclera collagen microstructure and mechanics, showing it captures both fiber-level interactions and macroscale behavior better than conventional continuum models.

Comparing acute IOP-induced lamina cribrosa deformations pre-mortem and post-mortem

The paper compares acute IOP-induced lamina cribrosa deformations in monkeys pre-mortem and post-mortem, finding similar trends but smaller pre-mortem deformations overall with local variations.

A broad and potent neutralization epitope in SARS-related coronaviruses

The paper identifies a broadly neutralizing epitope in SARS-related coronaviruses that is effective against variants, including Omicron, and suggests its use for universal vaccine design.

Anticancer immunotherapies transition postcapillary venules into high-endothelial venules that generate TCF1+ T lymphocyte niches through a feed-forward loop

This paper shows that antiangiogenic immunotherapies convert postcapillary venules into high-endothelial venules that support TCF1+ T cell niches through a feed-forward loop involving CD8 and NK cells.

Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy

This paper demonstrates that instant polarized light microscopy (IPOL) can visualize and quantify collagen morphology and architecture changes in the optic nerve head under dynamic loading.

Lamina cribrosa vessel and collagen beam networks are distinct

The paper quantifies the spatial relationship between vascular and collagen networks in monkey lamina cribrosa, finding they are distinct with most beams lacking vessels and many vessels outside beams.

SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies

SARS-CoV-2 Beta variant infection generates lineage-specific antibodies and cross-reactive antibodies with neutralizing activity against wild-type and other variants.

Screening of cell-virus, cell-cell, gene-gene interactions among kingdoms of life at single cell resolution

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography

This paper introduces a high-accuracy and high-efficiency digital volume correlation method to analyze in-vivo optic nerve head biomechanics from OCT data, showing improved performance over conventional methods.

Viral receptor profiles of masked palm civet revealed by single-cell transcriptomics

The paper uses single-cell transcriptomics to profile viral receptor expression in masked palm civets, identifying potential tissue tropisms for 132 viruses.

Oxidations and amino acid substitutions in urinary proteins are the distinguishing characteristics of aging

This study identifies multi-site oxidations and amino acid substitutions in urinary proteins as age-related features by comparing three age groups using mass spectrometry and statistical analysis.

Role of Anti-SARS-CoV-2 antibodies in different cohorts: Can they provide clues for appropriate patient triaging?

This study examines the correlation between anti-SARS-CoV-2 antibodies and molecular testing in different patient cohorts to assess their utility in patient triaging.

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

Structural basis of a public antibody response to SARS-CoV-2

The paper identifies IGHV3-53 as a common VH gene for SARS-CoV-2 neutralizing antibodies and determines its structural basis for binding the RBD.

Resolving an underrepresented circulating tumor cell population in lung cancer enabled by Hexokinase 2 analysis

This study identifies HK2 as a marker for detecting underrepresented CTCs in NSCLC, revealing a distinct subpopulation with unique characteristics.

Urine proteome changes in an α-synuclein transgenic mouse model of Parkinson's disease

The paper analyzes urine proteome changes in α-synuclein transgenic mice to identify proteins associated with Parkinson's disease progression.

Are pangolins the intermediate host of the 2019 novel coronavirus (2019-nCoV) ?

This study analyzes pangolin coronaviruses to assess their role as potential intermediate hosts of SARS-CoV-2, finding genetic relatedness but not direct origin.

Girdin: an essential component of pre-replicative complex in human cells

This study identifies Girdin as an essential replication initiation factor in human cells, required for pre-RC assembly by recruiting Cdc6 to DNA origins.

A device to collect exhaled breath to study biomarkers in small animal models

The paper describes a device for collecting exhaled breath from small animals to study biomarkers in a rat model of pulmonary emphysema.

Clonal seeds in hybrid rice using CRISPR/Cas9

This paper demonstrates the use of CRISPR/Cas9 to enable clonal propagation of hybrid rice through seeds by fixing heterozygosity in F1 hybrids.