New design strategies for ultra-specific CRISPR-Cas13a-based RNA-diagnostic tools with single-nucleotide mismatch sensitivity
Adrian Moises Molina Vargas, Souvik Sinha, Raven M. Osborn, Pablo R Arantes, Amun C. Patel, Stephen Dewhurst, Dwight J. Hardy, Andrew Cameron, Giulia Palermo, Mitchell R. O’Connell
This paper develops new CRISPR-Cas13a variants and crRNA design strategies to improve RNA-detection specificity, achieving better discrimination of SARS-CoV-2 strains.
Nucleic Acids Research · Nov 9, 2023Peer-reviewedMolecular Biology