Author

Amun C. Patel

University of California, RiversideORCID 0000-0002-7119-2973Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Giulia PalermoiD· 2 shared Souvik SinhaiD· 2 shared Adrian Moises Molina VargasiD· 1 shared Andrew CameroniD· 1 shared Dwight J. Hardy· 1 shared Mitchell R. O’ConnelliD· 1 shared Pablo R Arantes· 1 shared Pablo Ricardo ArantesiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiophysics

Giulia PalermoORCID

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2 papers

Recent·Most cited

Unveiling Cas8 Dynamics and Regulation within a transposon-encoded Cascade-TniQ Complex

Amun C. Patel, Souvik Sinha, Pablo Ricardo Arantes, Giulia Palermo

This study reveals the conformational dynamics of the Cas8 protein in the Cascade-TniQ complex, showing how it transitions between open and closed states to facilitate DNA binding and transposition.

Proceedings of the National Academy of Sciences · Apr 2, 2025Peer-reviewedBiophysics

New design strategies for ultra-specific CRISPR-Cas13a-based RNA-diagnostic tools with single-nucleotide mismatch sensitivity

Adrian Moises Molina Vargas, Souvik Sinha, Raven M. Osborn, Pablo R Arantes, Amun C. Patel, Stephen Dewhurst, Dwight J. Hardy, Andrew Cameron, Giulia Palermo, Mitchell R. O’Connell

This paper develops new CRISPR-Cas13a variants and crRNA design strategies to improve RNA-detection specificity, achieving better discrimination of SARS-CoV-2 strains.

Nucleic Acids Research · Nov 9, 2023Peer-reviewedMolecular Biology