Promiscuous RNA binding by WDR5 remodels the KMT2A (MLL1) histone methyltransferase complex to an inactive state
Amoldeep S. Kainth, Pallavi Sirjoosingh, Michael S. Werner, Ankit Gupta, Akiko Koide, Shohei Koide, Alexander J. Ruthenburg
The paper shows WDR5 binds RNA non-specifically, displacing it from the MLL1 complex and inhibiting its catalytic activity.
Molecular Cell · Aug 31, 2026Peer-reviewedMolecular Biology