Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly
Zishuo Yu, Pradeep Sathyanarayana, Cong Liu, Joel M. J. Tan, Pan pan Yang, Biswajit Das, Side Hu, Xiaoyi Fan, Chenggong Ji, Sandra K. Weller, Mrinal Shekhar, Donald M. Coen, Philip J. Kranzusch, Joseph J. Loparo, Jonathan Abraham
This study determines the structure of HSV-1 helicase-primase inhibited by HPIs and reveals how it interacts with the replication fork complex.
Cell · Dec 29, 2025Peer-reviewedMicrobiology