Sandra K. Weller

This study presents cryo-EM structures of herpesvirus packaging accessory factors, revealing conserved pentameric symmetry and a critical positively charged central channel for genome packaging.

This paper identifies small molecule inhibitors of herpesvirus alkaline nucleases that show broad antiviral activity against HSV-1 and HCMV.

This study identifies a novel nucleic acid-binding module, PXL, in PML-1 and shows it binds G-rich RNA/DNA and modulates the transcriptome.

This study determines the structure of HSV-1 helicase-primase inhibited by HPIs and reveals how it interacts with the replication fork complex.

This paper shows that HSV-1's ICP22 protein functions as a viral J-like co-chaperone that interacts with Hsc70 to manage protein aggregation during lytic infection.