Chenggong Ji

This study determines cryo-EM structures of orthoflaviviruses bound to LDLR family receptors, revealing distinct binding modes and receptor engagement mechanisms.

This study identifies the molecular basis of chikungunya virus recognition of the mosquito-specific receptor Lachesin using cryo-EM structures and shows a Lachesin polymorphism that blocks virus entry.

This study determines the structure of HSV-1 helicase-primase inhibited by HPIs and reveals how it interacts with the replication fork complex.

The paper presents the cryo-EM structure of Xenopus IgX, revealing a hexameric assembly that informs strategies for engineering human IgM and IgG hexamers with therapeutic applications.

This study identifies CD5L as a component of IgM pentamers, showing it binds to the J chain via a disulfide bond and reduces IgM binding to pIgR.

The paper reports the cryo-EM structure of a potent SARS-CoV-2 NAb, BD-368-2, showing it blocks ACE2 binding and induces structural changes in the spike trimer, distinct from other NAbs.