Sephin1 rewires proteostasis through actin-dependent signaling
Giulia Frapporti, Antonella Capuozzo, Eleonora Colombo, Paolo Fioretti, Vincenzo Maria D’Amore, Francesco Saverio Di Leva, Adriano Lama, Vasvi Tripathi, Stefano Medaglia, Stephanie Waich, Caterina Montani, Maria Dolores Perez-Carrion, Antonella Marte, Franco Onofri, Christian Johannes Gloeckner, , Giovanni Piccoli
This study identifies sephin1's mechanism of action in proteostasis disruption by showing it binds G-actin, causes cytoskeleton misfolding, and modulates autophagy through mTORC1-TFEB and GCN2-eIF2-CHOP pathways.
bioRxiv · Jun 3, 2026 · PreprintCell Biology