Author

Giulia Frapporti

Eurac Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Adriano LamaiD· 1 shared Alberto BoldriniiD· 1 shared Alessandro GalbiatiiD· 1 shared Alexandros PatsilinakosiD· 1 shared Andrea AstolfiiD· 1 shared Andrew A. HicksiD· 1 shared Anne-Marie Castonguay· 1 shared Antonella CapuozzoiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCell Biology

Adriano LamaORCID

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Author profile →

3 papers

Recent·Most cited

Protein Folding Interference Enables Selective Cyclin D1 Degradation

Alessandro Galbiati, Enrica Colasurdo, Alexandros Patsilinakos, Simone Lanfredini, Serena Bonifati, Tania Massignan, Carmine Varricchio, Leda Bencheva, Alberto Boldrini, Luca Terruzzi, Gianluca Papeo, Andrea Astolfi, Laura Raggi, Marta Pandini, Giulia Frapporti, , Giovanni Spagnolli

This paper identifies a folding intermediate of Cyclin D1 as a target for selective degradation, showing that pharmacological interference with this state inhibits tumor growth and overcomes resistance to CDK4/6 inhibitors.

bioRxiv · Oct 25, 2026 · PreprintBiochemistry

Sephin1 rewires proteostasis through actin-dependent signaling

Giulia Frapporti, Antonella Capuozzo, Eleonora Colombo, Paolo Fioretti, Vincenzo Maria D’Amore, Francesco Saverio Di Leva, Adriano Lama, Vasvi Tripathi, Stefano Medaglia, Stephanie Waich, Caterina Montani, Maria Dolores Perez-Carrion, Antonella Marte, Franco Onofri, Christian Johannes Gloeckner, , Giovanni Piccoli

This study identifies sephin1's mechanism of action in proteostasis disruption by showing it binds G-actin, causes cytoskeleton misfolding, and modulates autophagy through mTORC1-TFEB and GCN2-eIF2-CHOP pathways.

bioRxiv · Jun 3, 2026 · PreprintCell Biology

Rit2 reduces LRRK2 kinase activity and protects against alpha-synuclein neuropathology

Julia Obergasteiger, Anne-Marie Castonguay, Giulia Frapporti, Evy Lobbestael, Veerle Baekelandt, Andrew A. Hicks, Peter Paul Pramstaller, Claude Gravel, Corrado Corti, Martin Lévesque, Mattia Volta

This study shows that RIT2 inhibits LRRK2 kinase activity, reduces aSyn inclusions, and protects neurons in Parkinson's disease models.

bioRxiv · Oct 21, 2020 · PreprintNeuroscience