Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies
Arden Darko-Boateng, Emmanuel Afriyie, Travis J. Morgenstern, Sri Karthika Shanmugam, Xinle Zou, Yianni D. Laloudakis, Papiya Choudhury, Meera Desai, Robert S. Kass, Francesca Vallese, Oliver B. Clarke, Henry M. Colecraft
This study demonstrates the use of divalent nanobodies to recruit NEDD4-2 E3 ligase to degrade ion channels, reducing their function with minimal off-target effects.
Nature Communications · Dec 6, 2025Peer-reviewedBiophysics