Oliver B. Clarke

This study identifies the RY12 domain of RyR1 as an ADP sensor and reveals dantrolene's binding mechanism through cryo-EM structures.

This study determines the high-resolution structures of stomatin complexes with AQP-1 and UT-B, revealing their structural basis of association and role in erythrocyte osmotic balance.

This study presents a 2.25 Å cryo-EM structure of the vault cap, revealing a 13-fold symmetric arrangement and a positively charged exterior with implications for vault function and therapeutic applications.

This study demonstrates the use of divalent nanobodies to recruit NEDD4-2 E3 ligase to degrade ion channels, reducing their function with minimal off-target effects.

The paper presents the cryo-EM structure of a nematode LGR dimer, providing insights into the evolution and function of glycoprotein hormone receptors.

This study uses cryo-EM and molecular dynamics to analyze conformational transitions in AE1 and shows how PIP2 lipids inhibit transport by stabilizing the outward-facing state.

This paper presents a workflow for cryo-EM structure determination of small proteins using heterogeneous ab initio reconstruction, successfully solving structures of three small proteins with resolutions below 5 Å.

The paper introduces cryoDRGN-AI, a method for ab initio 3D reconstruction of cryo-EM and cryo-ET datasets, revealing new conformational states and unresolved motions.

TARDIS is a deep learning framework that rapidly and accurately segments membranes and filaments in electron microscopy data, enabling large-scale biophysical analysis.