Xinle Zou

This study demonstrates the use of divalent nanobodies to recruit NEDD4-2 E3 ligase to degrade ion channels, reducing their function with minimal off-target effects.

This study uses engineered deubiquitinases to investigate how different polyubiquitin linkages regulate KCNQ1 functional expression and trafficking, revealing distinct roles for each linkage type.

This paper develops chambered cardiac organoids (CCOs) that model cardiac chamber formation and assess cardiotoxicity through morphological and functional responses to toxic compounds.